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Nicotine is a potent parasympathomimetic alkaloid found in the nightshade family of plants (Solanaceae) and a stimulant drug. Nicotine is a nicotinic acetylcholine receptor (nAChR) agonist, except at nAChRα9 and nAChRα10 where it acts as an antagonista. It is made in the roots of and accumulates in the leaves of the nightshade family of plants. It constitutes approximately 0.6–3.0% of the dry weight of tobacco and is present in the range of 2–7 µg/kg of various edible plants. It functions as an antiherbivore chemical; consequently, nicotine was widely used as an insecticide in the past and nicotine analogs such as imidacloprid are currently widely used.In lesser doses (an average cigarette yields about 2 mg of absorbed nicotine), the substance acts as a stimulant in mammals, while high amounts (50–100 mg) can be harmful. This stimulant effect is a major contributing factor to the addictive properties of tobacco smoking.icotine's mood-altering effects are different by report: in particular it is both a stimulant and a relaxant. First causing a release of glucose from the liver and epinephrine (adrenaline) from the adrenal medulla, it causes stimulation. Users report feelings of relaxation, sharpness, calmness, and alertness. Like any stimulant, it may very rarely cause the often uncomfortable neuropsychiatric effect of akathisia. By reducing the appetite and raising the metabolism, some smokers may lose weight as a consequence.

When a cigarette is smoked, nicotine-rich blood passes from the lungs to the brain within seven seconds and immediately stimulates the release of many chemical messengers such as acetylcholine, norepinephrine, epinephrine, arginine vasopressin, serotonin, dopamine, and beta-endorphin. This release of neurotransmitters and hormones is responsible for most of nicotine's psychoactive effects. Nicotine appears to enhance concentration and memory due to the increase of acetylcholine. It also appears to enhance alertness due to the increases of acetylcholine and norepinephrine. Arousal is increased by the increase of norepinephrine. Pain is reduced by the increases of acetylcholine and beta-endorphin. Anxiety is reduced by the increase of beta-endorphin. Nicotine also extends the duration of positive effects of dopamine and increases sensitivity in brain reward systems. Most cigarettes (in the smoke inhaled) contain 1 to 3 milligrams of nicotine.

Studies suggest that when smokers wish to achieve a stimulating effect, they take short quick puffs, which produce a low level of blood nicotine. This stimulates nerve transmission. When they wish to relax, they take deep puffs, which produce a higher level of blood nicotine, which depresses the passage of nerve impulses, producing a mild sedative effect. At low doses, nicotine potently enhances the actions of norepinephrine and dopamine in the brain, causing a drug effect typical of those of psychostimulants. At higher doses, nicotine enhances the effect of serotonin and opiate activity, producing a calming, pain-killing effect. Nicotine is unique in comparison to most drugs, as its profile changes from stimulant to sedative/pain killer in increasing dosages and use, a phenomenon described by Paul Nesbitt in his doctoral dissertation and subsequently referred to as "Nesbitt's Paradox".

By binding to nicotinic acetylcholine receptors, nicotine increases the levels of several neurotransmitters – acting as a sort of "volume control". It is thought that increased levels of dopamine in the reward circuits of the brain are a major contributor to the apparent euphoria and relaxation, and addiction caused by nicotine consumption. Nicotine-induced dopamine release occurs via the cholinergic–dopaminergic reward link, which is mediated by the neuropeptide ghrelin in the ventral tegmentum. Nicotine has a higher affinity for acetylcholine receptors in the brain than those in skeletal muscle, though at toxic doses it can induce contractions and respiratory paralysis. Nicotine's selectivity is thought to be due to a particular amino acid difference on these receptor subtypes.

Tobacco smoke contains anabasine, anatabine, and nornicotine. It also contains the monoamine oxidase inhibitors harman and norharman. These beta-carboline compounds significantly decrease MAO activity in smokers. MAO enzymes break down monoaminergic neurotransmitters such as dopamine, norepinephrine, and serotonin. It is thought that the powerful interaction between the MAOIs and the nicotine is responsible for most of the addictive properties of tobacco smoking. The addition of five minor tobacco alkaloids increases nicotine-induced hyperactivity, sensitization and intravenous self-administration in rats.

Chronic nicotine exposure via tobacco smoking up-regulates alpha4beta2* nAChR in cerebellum and brainstem regions but not habenulopeduncular structures. Alpha4beta2 and alpha6beta2 receptors, present in the ventral tegmental area, play a crucial role in mediating the reinforcement effects of nicotine.

Research published in 2011 found that nicotine inhibits class I and II histone deacetylases, chromatin-modifying enzymes involved in epigenetics. This inhibition has been shown to increase susceptibility to cocaine addiction in rodents

Nicotine also activates the sympathetic nervous system, acting via splanchnic nerves to the adrenal medulla, stimulating the release of epinephrine. Acetylcholine released by preganglionic sympathetic fibers of these nerves acts on nicotinic acetylcholine receptors, causing the release of epinephrine (and noradrenaline) into the bloodstream. Nicotine also has an affinity for melanin-containing tissues due to its precursor function in melanin synthesis or due to the irreversible binding of melanin and nicotine. This has been suggested to underlie the increased nicotine dependence and lower smoking cessation rates in darker pigmented individuals. However, further research is warranted before a definite conclusive link can be inferred.

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I create Lolita Slave Toys. In case you are wondering what I mean, it is very simple: I transform young girls into easy, manageable sex toys. That's it. The girls can not walk away, can not resist, can not tell anything; they are just there for your sadistic amusement.

Curious how?

I am a surgeon living in one of those countries at the eastern outskirts of Europe. A pretty rough society still, poverty is enormous, and unless you have money and connections, you are fucked. Needless to say, I have both. We also have beautiful girls here, Eastern European countries are well known for that. Fortunately (for me), some of these girls don't have parents or relatives anymore and live in orphanages. Actually, I would not call that living, it is unbelievable what you will find there.

Some very young girls are lucky and get adopted, but at an age of 8 or 9 they are too old. Some of the more pretty girls get sold into prostitution, and you could consider it luck for them too, instead of slowly fading away in filth and poverty. And a few girls I buy. I generally pick the attractive girls around 9 or 10 years, before puberty starts. The orphanage is very cooperative, they are glad they have one mouth less to feed, one new place to fill. They also gladly accept my donations for the girls. They never ask and I never tell. They know I am a surgeon; they probably think I do some experiments with the girls or cut out and sell their organs.

But no, I found a much more profitable business: I turn the girls into sex toys. You can order a Lolita Slave Toy if you want. They are not cheap; I charge in between 30.000 and 40.000 US dollars for a toy. That is without shipping costs. But: you will have a Lolita Slave Sex Toy that will give you satisfaction for many years, she is like a doll, but she is a living doll! Let me tell you how I turn a young orphan girl into a living doll. When I have found a new, suitable girl, I will ask the orphanage to deliver her at my villa. She will arrive naked, tied and blindfold. After a brief inspection and a quick medical check, I will take her to my special clinic in my villa. First, I will clean her very thoroughly. These girls really smell and are filthy; they have not seen a bath for ages and they are really neglected. When she is finally clean, I put her in a hospital bed and give her an injection that will put her to sleep.

I will create her a new identity and give her a new name - I don't know the girls' real names, I just know their age; that's all I need. At the orphanage, any data they have from her will be destroyed. She never existed. She will from now on only exist as a toy. I have a couple of Lolita Slave Toys myself; Dasha, who is 11 years old and is just in the final stage of her transformation, Tanya, who is now 12 years old, two years since I created her, and Luda, who is 14 years old and 4 months pregnant. The next morning is the big operation day. The girl will be still sleeping because of the anesthetic from last night. I put her on the operation table and administer anesthetics for the operation to come.

So if you were wondering why my Slave Toy will not resist or walk away, very simple: I amputate her legs and arms! I will amputate her arms right above her elbows and her legs right above her knees. Easy, isn't it? This girl will never run away from you... For the girl this is a very heavy operation and it is probably the most critical step in the transformation process. But most of the times they survive. Now, I am not just leaving the girls with stumps on their arms and legs. I will attach a 5 cm metal bar very tightly to the bone on her arms and legs before stitching up the wounds.

The other end of the metal bar has a screw thread, where I can attach an o-ring. When she is ready, you easily secure her with a chain or padlock to any object you like! My Tanya and Luda normally have a chain behind their back attached to both o-rings on the stumps of their arms. It will keep their arms nicely close to their body. In the beginning you have to really take care of the wounds on the stumps to prevent infections. Once the wound is healed completely, I will place a silicone cover over the stump. The outside of the cover is covered with white velvet and this actually looks quite sweet, despite the rather cruel o-rings at the end of what is left of her arms and legs. After a few months, when the legs and arms have fully recovered you can put some more strain on the o-rings. I started a year ago to hang Tanya and Luda on their arms and legs from the ceiling.

It is such an interesting form of decoration in your room to have a naked Lolita hanging from your ceiling! And it is very nice to use her cunt or mouth when she is hanging like that. But before that it is a long way to go. The operation is not ready yet with amputating her arms and legs. Next I will also cut her vocal cords, so she can no longer speak or even make noises, and remove her teeth from her mouth. When I have removed all her teeth I implant a silicone layer with a soft top layer on her jaws. She will still be able to give blowjobs, but she can no longer bite on your dick. It is actually quite nice now, when she more or less chews a little bit on your cock; the soft top layer gives you a kind of massage. The silicone implant is however absolutely necessary; if not, her mouth would look like a toothless granny's. This will keep her good looks.

 

 

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Anime (Japanese: アニメ?, [anʲime] ( listen)) is a term used to refer to Japanese animated productions featuring hand-drawn or computer animation. The word is the abbreviated pronunciation of "animation" in Japanese, where this term references all animation. The meaning of the word anime can vary slightly, definitions include animation from Japan or, alternatively, a Japanese-disseminated animation style often characterized by colorful graphics, vibrant characters and fantastic themes. Arguably, the stylization approach to the meaning may open up the possibility of anime produced in countries other than Japan. For simplicity, many Westerners strictly view anime as an animation product from Japan. Some scholars suggest defining anime as specifically or quintessentially Japanese may be related to a new form of orientalism.

The earliest commercial Japanese animation dates to 1917, and production of anime works in Japan has since continued to increase steadily. The characteristic anime art style emerged in the 1960s with the works of Osamu Tezuka and spread internationally in the late twentieth century, developing a large domestic and international audience. Anime is distributed theatrically, by television broadcasts, directly to home media, and over the internet and is classified into numerous genres targeting diverse broad and niche audiences.

Anime is a diverse art form with distinctive production methods and techniques that have been adapted over time in response to emergent technologies. The production of anime focuses less on the animation of movement and more on the realism of settings as well as the use of camera effects, including panning, zooming and angle shots. Diverse art styles are used and character proportions and features can be quite varied, including characteristically large emotive or realistically sized eyes.

The anime industry consists of over 430 production studios including major names like Studio Ghibli, Gainax and Toei Animation. Despite having a fraction of the domestic film market, anime achieves a majority of DVD sales and has been an international success after the rise of televised English dubs. This rise in international popularly has resulted in non-Japanese productions using the anime art style, but these works have been defined as anime-influenced animation by both fans and the industry.

Anime is an art form, specifically animation, that includes all genres found in cinema, but it can be mistakenly classified as a genre. In Japan, the term anime refers to all forms of animation from around the world. English-language dictionaries define anime as a "Japanese-style animated film or television entertainment" or as "a style of animation created in Japan".

The etymology of the word anime is disputed. The English term "animation" is written in Japanese katakana as アニメーション (animēshon, pronounced [animeːɕoɴ]), and is アニメ (anime) in its shortened form. Some sources claim that anime derives from the French term for animation, dessin animé, but others believe this to be a myth derived from the French popularity of the medium in the late 1970s and 1980s. In English, anime, when used as a common noun, normally functions as a mass noun (for example: "Do you watch anime?", "How much anime have you collected?"). Prior to the widespread use of anime, the term Japanimation was prevalent throughout the 1970s and 1980s. In the mid-1980s, the term anime began to supplant Japanimation. In general, the term now only appears in period works where it is used to distinguish and identify Japanese animation.

In 1987, Hayao Miyazaki stated that he despised the truncated word "Anime" because to him it represented the desolation of the Japanese animation industry. He equated the desolation with animators lacking motivation and mass-produced, overly expressive products which rely on fixed iconography for facial expressions and protracted and exaggerated action scenes but lack depth and sophistication because they do not attempt to convey emotion or thought.

Anime are often classified by target demographic, including kodomo (children's), shōjo (girls'), shounen (boys') and a diverse range of genres targeting an adult audience. Shoujo and shounen anime sometimes contain elements popular with children of both sexes in an attempt to gain crossover appeal. Adult anime may feature a slower pace or greater plot complexity that younger audiences typically find unappealing, as well as adult themes and situations.:44–48 A subset of adult anime works feature pornographic elements and are labeled "R18" in Japan, but internationally these works are grouped together under the term hentai (Japanese for "pervert"). By contrast, a variety of anime subgenres across demographic groups incorporate ecchi, sexual themes or undertones without depictions of sexual intercourse, as typified in the comedic or harem genres; due to its popularity among adolescent and adult anime enthusiasts, incorporation of ecchi elements in anime is considered a form of fan service.

Anime's genre classification is different from other types of animation and does not lend itself to simple identity. Gilles Poitras compared the labeling Gundam 0080 and its complex depiction of war as a "giant robot" anime akin to simply labeling War and Peace a "war novel". Science fiction is a major anime genre and includes important historical works like Tezuka's Astro Boy and Yokoyama's Tetsujin 28-go. A major subgenre of science fiction is mecha, with the Gundam metaseries being iconic. The diverse fantasy genre includes works based on Asian and Western traditions and folklore; examples include the Japanese feudal fairytale InuYasha, and the depiction of Scandinavian goddesses who move to Japan to maintain a computer called Yggdrasil in Oh My Goddess. Genre crossing in anime is also prevalent, such as the blend of fantasy and comedy in Dragon Half, and the incorporation of slapstick humor in the crime anime Castle of Cagliostro. Other subgenres found in anime include magical girl, harem, sports, martial arts, literary adaptations, medievalism, and war.

Genres have emerged that explore homosexual romances. While originally pornographic in terminology, yaoi (male homosexuality) and yuri (female homosexuality) are broad terms used internationally to describe any focus on the themes or development of romantic homosexual relationships. Prior to 2000, homosexual characters were typically used for comedic effect, but some works portrayed these characters seriously or sympathetically

 

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Nicolas Kim Coppola (born January 7, 1964), known professionally as Nicolas Cage, is an American actor and producer. He has performed in leading roles in a variety of films, ranging from romantic comedies and dramas to science fiction and action films. In the early years of his career, Cage starred in films such as Valley Girl (1983), Racing with the Moon (1984), Birdy (1984), Peggy Sue Got Married (1986), Raising Arizona (1987), Moonstruck (1987), Vampire's Kiss (1989), Wild at Heart (1990), Honeymoon in Vegas (1992), and Red Rock West (1993).Cage received an Academy Award, a Golden Globe, and Screen Actors Guild Award for his performance as an alcoholic Hollywood writer in Leaving Las Vegas (1995) before coming to the attention of wider audiences with mainstream films such as The Rock (1996), Face/Off (1997), Con Air (1997), City of Angels (1998), and National Treasure (2004). He earned his second Academy Award nomination for his performance as Charlie and Donald Kaufman in Adaptation (2002). In 2002, he directed the film Sonny, for which he was nominated for Grand Special Prize at Deauville Film Festival. Cage owns the production company Saturn Films and has produced films such as Shadow of the Vampire (2000) and The Life of David Gale (2003).Through his performances in The Weather Man (2005), Lord of War (2005), The Bad Lieutenant: Port of Call New Orleans (2009), and Kick-Ass (2010) he earned critical acclaim. Films such as Ghost Rider (2007) and Knowing (2009) were box office successes. Cage has been strongly criticized in recent years for his choice of roles, some of which have been universally panned. However, he recently starred in The Croods and Joe, both of which were warmly received by critics.

Since his film debut with a minor role in Fast Times at Ridgemont High (1982), opposite Sean Penn, Cage has appeared in a wide range of films, both mainstream and offbeat. He auditioned for the role of Dallas Winston in his uncle's film The Outsiders, based on S.E. Hinton's novel, but lost to Matt Dillon. He was also in Coppola's films Rumble Fish[14] and Peggy Sue Got Married.Other Cage roles included appearances in the acclaimed 1987 romantic-comedy film Moonstruck, also starring Cher; the Coen Brothers cult-classic comedy Raising Arizona; David Lynch's 1990 film Wild at Heart; a lead role in Martin Scorsese's 1999 New York City paramedic drama Bringing Out the Dead; and Ridley Scott's 2003 drama film Matchstick Men, in which he played an agoraphobic, mysophobic, obsessive-compulsive con artist with a tic disorder.Cage has been nominated twice for an Academy Award, winning once for his performance as a suicidal alcoholic in Leaving Las Vegas. His other nomination was for his portrayal of real-life screenwriter Charlie Kaufman and Kaufman's fictional twin Donald in Adaptation. Despite these successes, most of his lower-profile films have performed poorly at the box office compared to his mainstream action/adventure roles. The suspense thriller 8mm (1999) is considered a cult film. He took the lead role in the 2001 film Captain Corelli's Mandolin and learned to play the mandolin from scratch for the part. He made his directorial debut with 2002's Sonny. In 2005, two films he headlined, Lord of War and The Weather Man, failed to find a significant audience despite nationwide releases and good reviews for his performances. Poor reviews for The Wicker Man resulted in low box office sales. The much criticized Ghost Rider (2007), based on the Marvel Comics character, fared better, earning more than $45 million (the top earner) during its opening weekend and over $208 million worldwide through the weekend ending on March 25, 2007. Also in 2007, he starred in Next, which shared the concept of a glimpse into an alternate timeline with Cage's film, The Family Man (2000).Most of Cage's movies that have achieved financial success were in the action/adventure genre. In his second-highest grossing film to date, National Treasure, he plays an eccentric historian who goes on a dangerous adventure to find treasure hidden by the Founding Fathers of the United States. Other action hits include The Rock, in which Cage plays a young FBI chemical weapons expert who infiltrates Alcatraz Island in hopes of neutralizing a terrorist threat, Face/Off, a John Woo film where he plays both a hero and a villain, and World Trade Center, director Oliver Stone's film regarding the September 11, 2001 attacks. He had a small but notable role as the Chinese criminal mastermind Dr. Fu Manchu in Rob Zombie's fake trailer Werewolf Women of the S.S. from the B-movie double feature Grindhouse.

In November 2007, Cage was spotted backstage at a Ring of Honor wrestling show in New York City researching for the lead role for The Wrestler. However, Cage dropped out of production shortly afterwards because he felt he did not have enough time to prepare for the role and director Darren Aronofsky preferred Mickey Rourke for the lead part. Rourke would go on to receive an Academy Award nomination for his performance. In an interview with slashfilm.com, Aronofsky said of Cage's decision to leave the film that: "Nic was a complete gentleman, and he understood that my heart was with Mickey and he stepped aside. I have so much respect for Nic Cage as an actor and I think it really could have worked with Nic but ... you know, Nic was incredibly supportive of Mickey and he is old friends with Mickey and really wanted to help with this opportunity, so he pulled himself out of the race."

In 2008, Cage appeared as Joe, a contract killer who undergoes a change of heart while on a work outing in Bangkok, in the film Bangkok Dangerous. The film is shot by the Pang Brothers and has a distinct South-East Asian flavor. In 2009, Cage starred in science fiction thriller Knowing, directed by Alex Proyas. In the film, he plays an MIT professor who examines the contents of a time capsule unearthed at his son's elementary school. Startling predictions found inside the capsule that have already come true lead him to believe the world is going to end at the close of the week, and that he and his son are somehow involved in the destruction.[36] The film received mainly negative reviews but was the box office winner on its opening weekend. Also in 2009, Cage starred in the film The Bad Lieutenant: Port of Call New Orleans, directed by acclaimed German director Werner Herzog. He portrayed a corrupt police officer with gambling, drug and alcohol addictions. The film was very well received by critics, holding a rating of 87% positive reviews on review aggregator website Rotten Tomatoes. Cage received lauds for his performance, with Michael Phillips of the Chicago Tribune writing "Herzog has found his ideal interpreter, a performer whose truth lies deep in the artifice of performance: ladies and gentlemen, Nicolas Cage, at his finest." This film reunited Cage with Eva Mendes, who played his love interest in Ghost Rider. In 2010, Cage starred in the period piece Season of the Witch, playing a 14th-century knight transporting a girl accused of causing the Black Plague to a monastery, and The Sorcerer's Apprentice, in which he played the sorcerer.

 In 2012, Cage reprised his role in Ghost Rider's sequel Ghost Rider: Spirit of Vengeance.[43] He voiced the character Grug Crood in the animated film The Croods, which was released in 2013. The Croods received positive reviews from critics and was a box office success grossing $585 million against a budget of $135 million

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To further keep her mouth in good shape, she will wear a ball gag most of the time. That does sound somewhat obsolete, because I cut her vocal cords and she cannot speak anyway, but this is just because of esthetics. A gagged girl simply looks good and besides feeding, drinking and fucking, she does not need her mouth anymore. Once the operation is ready, I will give the girl one or two weeks to recover and let the wound heal. Then her training begins. She is no longer an ordinary girl, but became a toy, there is a lot of things she has to learn. Since she has no teeth anymore, she cannot eat. She has to be fed again like a baby. I actually feed her once a day with a baby bottle and infant formula, because it contains all minerals and vitamins. I don't give her more; I don't want her to get fat, because she cannot more anymore.

You have to be careful with that. She gets to drink a baby bottle with water, tea or lemonade three or four times a day, so she gets at least 2 liters of liquid per day. That is sufficient to keep her healthy. In the beginning I will put the bottle in her mouth, but pretty soon I will just put the bottle next to her, so she has to put it in her mouth herself. It takes some practice to get the bottle in her mouth herself without having arms, but eventually she manages to grab a bottle with her mouth, roll on her back and drink. Once she gets the trick, I will blindfold her before she gets her bottle; before her training is finished, she must be able to find the bottle and drink it without being able to see. The food and drink has to come out again too, so you have to put her on the toilet a few times per day. Since she cannot move, you have to lift her up and bring her to the toilet. When I am out for business, I normally put a catheter in her urinary tract.

Since she does not eat much, she does not shit much either. Although she can no longer speak, I can still communicate with her [and] so teach her some elementary things. I will teach her to give a proper blowjob, I will teach her to enjoy sex when her clit and labia are stimulated with a vibrator. I will also teach her what it means to be a slave. I will whip her pussy every day, mostly in combination with using a vibrator, so she will at some point in time no longer be able to discriminate between pain and pleasure. I will put clamps and pegs on her nipples and labia, stretch her labia. I will intensify her training when I treat her pussy with more and more needles. Her pussy will be treated with hot wax, her clit will be tortured with needles, her cunt will be electrocuted, her cunt will be sewn shut.

Any possible form of torture she will have to endure before she gets to the next stage of her transformation. In this phase I will blindfold her most of the time, but I will take care she will also actually see how I torture her. I have a camera running most of the time, and she will have to watch her own torture, plus some more really hardcore torture movies, at least an hour per day. At some point in time she is not only physically a slave, but also became mentally a slave. Her mind no longer resists, she has become totally submissive. Then I will make the last modification to make her to a Slave Toy. She is already immobilized and unable to communicate herself, because no longer able to speak. Until now she was still able to see and hear, she was not completely sensory-deprived. A true Slave Toy can no longer move, speak, see or hear, but only feel. Before depriving her of her last senses I will give her a mild anesthetic.

Then I put headphones on her ears and play for several hours extremely loud noises on the headphones. This will be sufficient to damage her hearing for good, she will not be able to hear anymore. As a final touch I will treat her eyes with a laser. She will not be completely blind. My Tanya and Luda still react on strong lights, and I guess they can still see some faint shadows, but they cannot recognize anything anymore and they are almost deaf. Nevertheless I blindfold them most of the time, but that is because I like a blindfolded girl. They are completely numb, they don't even make noises when I torture them. I can only see from the reactions of her body, the increased speed of breathing, and the expression in her face she is suffering pain. When she has recovered from this, she is now transformed in a helpless little toy and ready for sale.

They are very easy to keep: just a little bit of food, need only a little bit of care (daily cleaning). They are immobilized, you can attach them to any object, and even make "decoration" out of them. They cannot speak, hear or see; they are completely sensory-deprived. The Slave Toys that are for sale are still virgin and just entering puberty. Nevertheless, they are well trained for oral sex and have been tortured and abused heavily. They can get pregnant, so anticonception is advised, unless you enjoy to have a pregnant slave toy. Just let me know if you want to order one.

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But what if I really want to win?

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Then you better keep posting.

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This makes me miss the Food Porn topic.

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his promo is so good   i miss him :'(

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