THis is serious business not time for memes.
Stanley Parable leans pretty damn hard on that fourth wall. Homestar Runner pretty much has no fourth wall at all. Some game that's name escapes me has you directly control a character, your actions either hiding or slowly revealing to the NPCs that the character is being "controlled" based on his behavior. It treats your being "The Player" more like possession.
A few games do that actually.
There's some fun tropes on it:
Breaking The Fourth Wall
The Fourth Wall Will Not Protect You
Leaning On The Fourth Wall
No Inner Fourth Wall
To clarify, it reminds me in the fashion of us being unable to see through our own fourth wall, this line of speculation.
I used to worry about that sort of thing.