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Mental Health & Pharmacology


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https://www.bluelight.org/xf/threads/bluelight-research-on-ketamine-as-a-treatment-for-depression-and-ptsd.889013/ 

 

aspiringchemist:

Jul 21, 2020
#5

"Thank you to the research team and whoever posted this. I have treatment resistant depression (dysthymia) and have been on various pharmacological treatments for decades; all the first line treatments. Ultimately I have wound up on amphetamine as it has been the only thing to provide consistent releif for years; initially bupropion provided some relief and thus realized that altering norepinephrine and dopamine relieves my depressive symptoms.

I had the opportunity to try ketamine recently in doses of 80mg and 100mg intranasally; note this is not in a medical setting. I noticed a great lift in symptoms of depression for the week following administration.

I am now very interested in trying this with a medical professional and intend to talk to my psychiatrist about it. Unfortunately all the ketamine clinics around my area refuse to provide treatment if you are taking benzodiazepines, which I am, and I'm not willing to stop right now.

I have used many tryptamines and phenethylamines throughout my life, though not in many years. The days in which I took those things regularly I recall feeling much less depressed and much more optimistic."

last edit on 4/29/2021 9:13:51 AM
Posts: 9601
0 votes RE: Mental Health & Pharmacology

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235744/ 

 ^Escitalopram is Associated with Reductions in Pain Severity and Pain Interference in Opioid Dependent Patients with Depressive Symptoms

 

https://www.nami.org/About-Mental-Illness/Treatments/Mental-Health-Medications/Types-of-Medication/Escitalopram-(Lexapro) 

 ^Serotonin Syndrome, Glaucoma, Interactions including amphetamines, and effects on low sodium. 

 

https://www.medicinenet.com/lexapro_escitalopram_side_effects/side-effects.htm#what_drugs_interact_with_lexapro_escitalopram 

 ^Resulting negative disorders and affects associated with Lexapro, and drug interactions 

 

https://www.drugs.com/drug-interactions/escitalopram-index.html 

 ^Lexapro drug interactions master list

last edit on 4/29/2021 9:08:21 AM
Posts: 9601
0 votes RE: Mental Health & Pharmacology

https://nootropicsexpert.com/best-nootropics-for-depression/ 

^Nootropics and depression 

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756795/ 

^Probable Nootropic induced Psychiatric Adverse Effects: A Series of Four Cases

 

https://www.verywellmind.com/what-are-alpha-brain-waves-5113721 

^Alpha brain waves and depression

last edit on 4/29/2021 9:18:13 AM
Posts: 9601
0 votes RE: Mental Health & Pharmacology

My personal thoughts about my prescribed treatment of Lexapro, abilify, and buspar... were they trying to kill me? Reading about Lexapro has helped me understand that abilify and buspar are two of the most interactive drugs with lexapro, and can commonly lead to serotonin syndrome. They did not screen me for signs of this syndrome prior to prescribing me it, nor afterward. 

 

In hospital I complained of symptoms such as my teeth were chattering constantly. The doctor literally looked at me, shrugged, and said, "that's weird."

(and when I took the Lexapro, Abilify, and Buspar all together, my entire body was in so much pain for 24 hours, I never wanted to take the combination again, I still don't understand the cause of this, but I wrote it off as a 'negative side affect' rather than any kind of adverse reaction. At the time I had also just recently detoxed from Benzodiazepine dependency, and figured the pain may of been a possible delayed withdrawal affect or, an excitatory affect known as 'neurotoxicity' common in patients who recently quit Benzodiazepine habitual use.)

 

A simple google search has me understanding this is a sign that this drug may not of been right for me, and I should of been monitored for serotonin syndrome at the very least. Or at least informed of it. No? 

 

When I was prescribed lexapro I asked the doctor, "are there any adverse affects or symptoms associated with this drug." and he flat out said one word. "No." I also asked, "is this a drug that can cause dependency, or that if I abruptly stopped, I could experience withdrawal from." He simply replied, "No." 

 

A simple google search has me understanding this is a false answer. He flat out lied to my face. There is no discrepancy here, and my questions were very clear and direct, as were his answers. 

 

Later on, I went on to experience muscle rigidity, another symptom of serotonin syndrome, which is more terrifying than they describe on paper. It was very reminiscent of the more frightening titled disorder, "locked in syndrome." And the only thing that relieved it was Benzodiazepines. Which had me thinking it was simply the symptom of a panic attack associated with my Post Traumatic Stress Disorder. 

 

I find it odd, switching gears here- that not a single psychiatrist or therapist informed me of nutrition and metabolic physiological health's affect on mental health. At this rate, as doctors, it is borderline negligent to prescribe a patient a medication, and not also inform them of vital and necessary basic dietary information that could be life altering, or at least refer them to a specialist to screen them for metabolic deficiencies and other potential causes of their depression. After all, it is important that physiological disorders of any kind are ruled out before diagnosing mental disorders, however, this step is often skipped by psychiatrists. What gives them the right to do so, without this being negligent of a patients health? 

 

Why is it difficult in todays day and age of modern technology and medicine (a practice under which there is much scrutiny and backing it- intensely refined educational standards) to find a comprehensively minded doctor who is fully attentive to their patient. 

last edit on 4/29/2021 9:38:38 AM
Posts: 9601
0 votes RE: Mental Health & Pharmacology

Note on amphetamines and depression: 

 

I find it very interesting that ketamine, and other use of low-dose amphetamines have shown promise for individuals with more chronic and treatment resistant forms of depression. Considering, when I met my first therapist after being discharged from residential psychiatric treatment, my first out patient therapist. She asked me,  "what have you been doing all this time to manage it?" meaning, prior to medication assistance. And I simply lifted up my coffee cup and said, "uh, with this." 

 

I thought I was being kind of funny but, then it had me asking, why is it that all these years the only thing that's ever truly helped is a stimulant? There has to be something evidential in that which can perhaps help me better understand the initial cause of my depression.  

 

So in this case, I find myself working backwards. I know what works, I just don't know why. So I research caffeine's neuropsychological effects and low and behold, it has to do with reducing inflammation in the brain, which results in increase motivation and dopamine, and a reduction in fatigue and other depression symptoms. 

 

So as a potential cause of depression, why is my brain potentially, chronically inflamed? As a lay person I thought, oh, must have to do with sodium. I must eat too much sodium! (lol) And then I go to see a wonderful functional medicine doctor, and she tells me I actually was quite low sodium, and could benefit dietarily from consuming salt. 

 

This is sort of conflicting information, and this is why treating depression is so messy. It can get quite tangled like this, and it's not simply a straight forward A+B=C sort of equation. Aka, "person is depressed, give person medicine, person is better now." It's much much more complex than that. 

 

And to add to the conundrum, Lexapro causes low sodium. 

last edit on 4/29/2021 9:54:51 AM
Posts: 2481
0 votes RE: Mental Health & Pharmacology

Hi Blanc what are you doing these days 

Posts: 9601
0 votes RE: Mental Health & Pharmacology
Med said: 

Hi Blanc what are you doing these days 

 Working

Posts: 2283
0 votes RE: Mental Health & Pharmacology

See? I am not a methhead, I am a self-medicator of dysthymia.

consumed by avarice
Posts: 34402
0 votes RE: Mental Health & Pharmacology
Blanc said: 
Med said: 

Hi Blanc what are you doing these days 

 Working

What kind of work? 

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