Personally I would not "experiment" except with very close friends I will still be able to be friends with even after a failed experiment goes bad. So that limits the scope of any such testing. If it is with people who were expendable, the chances of something going wrong are so great it aint worth it. And if it is with friends who can take the risks unconditionally with me, and still respect each other afterwards, usually those friends don't deserve to be experimented on. Are you looking to punish yourself? Does your brain need intense stimulation that badly you don't mind the cost and actually enjoy that as part of the thrill? What about the person you want to experiment with? If they have a disease you can never get rid of, is it still worth it to you?