That is exactly when clinicians start throwing drugs at people.It's legal in a lot of places now, and if you look into terpenes it's actually pretty neat.
Let's say I smoke marijuana. at any time my relatives or friends who need my help urgently can call me. I can get to them, being smoked with marijuana, but I will not be able to reason sensibly and make optimal decisions, simply because I am a smoky dumbass. :)
That really depends on what you're putting into your system.